The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Nasreddine ZS, Phillips NA, Bédirian V, et al. Functional boundaries in the human cerebellum revealed by a multi-domain task battery. King M, Hernandez-Castillo CR, Poldrack RA, Ivry RB, Diedrichsen J. Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Pediatric postoperative cerebellar cognitive affective syndrome follows outflow pathway lesions. Multivariate lesion-symptom mapping using support vector regression. Zhang Y, Kimberg DY, Coslett HB, Schwartz MF, Wang Z. The role of the cerebellum in cognition: beyond coordination in the central nervous system. Cognitive impairment in young adults with infratentorial infarcts. Malm J, Kristensen B, Karlsson T, Carlberg B, Fagerlund M, Olsson T. Neuropsychological disturbances in cerebellar infarcts. Neau JP, Arroyo-Anllo E, Bonnaud V, Ingrand P, Gil R. Cognitive functions in patients with MR-defined chronic focal cerebellar lesions. cognitive consequences in patients with cerebellar stroke. Stoodley CJ, MacMore JP, Makris N, Sherman JC, Schmahmann JD. Cerebellar stroke without motor deficit: clinical evidence for motor and non-motor domains within the human cerebellum. Reference values for the Cerebellar Cognitive Affective Syndrome Scale: age and education matter. Validation of a German version of the Cerebellar Cognitive Affective/ Schmahmann Syndrome Scale: preliminary version and study protocol. The Cerebellar Cognitive Affective/Schmahmann syndrome scale. Hoche F, Guell X, Vangel MG, Sherman JC, Schmahmann JD. Cognitive impairments due to focal cerebellar injuries in adults. 2015 3:1–8.Īlexander MP, Gillingham S, Schweizer T, Stuss DT. Behavioral disorders and cognitive impairment associated with cerebellar lesions. Grossauer S, Koeck K, Kau T, Weber J, Vince GH. Anatomical correlates of neuropsychological deficits among patients with the cerebellar stroke. The cerebellar cognitive affective syndrome. The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging. This study extends the understanding of long-term CCAS and introduces multivariate LSM methods to identify clinically intra- and cross-lobular significant regions underpinning chronic CCAS.īuckner RL. Our findings prove the usefulness of MoCA and CCAS-S to reveal cognitive impairments in patients with chronic acquired cerebellar lesions. These findings concurred with the anterior-sensorimotor/posterior-cognitive dichotomy in the human cerebellum and revealed clinically intra- and cross-lobular significant regions (portions of right lobule VI, VII, Crus I-II) for verbal tasks that overlap with the “language” functional boundaries in the cerebellum. Specifically, patients with chronic cerebellar lesions in right-lateralized posterolateral regions manifested cognitive impairments inherent to CCAS. However, only impairments determined by the CCAS-S resulted in significant regional localization within the cerebellum. MoCA and CCAS-S had an adequate test performance with efficient discrimination between patients and healthy volunteers. The neural bases underpinning both tests were explored with multivariate lesion-symptom mapping (LSM) methods. CCAS-S and MoCA were administrated to 22 patients with isolated chronic cerebellar strokes and a matched comparison group. The objective of this research is to prove and contrast the usefulness of the CCAS-S and the Montreal Cognitive Assessment (MoCA) test to evaluate cognitive/affective impairments in patients with chronic acquired cerebellar lesions, and to map the cerebellar areas whose lesions correlated with dysfunctions in these tests. However, studies with chronic patients have had controversial findings that have not been explored with new cerebellar-target tests, such as the CCAS scale (CCAS-S). The cerebellar cognitive affective syndrome (CCAS) has been consistently described in patients with acute/subacute cerebellar injuries.
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